Indocyanine green Chemical Properties

Melting point:

235 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H2O: soluble1mg/mL

form 

Powder

color 

Green-bronze

Appearance

Dark green solid

Water Solubility 

slightly soluble

ex/em

786/820nm (Methanol)

Φ(quantum yield)

0.09

ε(extinction coefficient)

≥115 at 386-396nm in water
≥2000 at 774-784nm in water
≥900 at 712-722nm in water

Merck 

14,4962

BRN 

4115884

InChIKey

JDDBTPDPBRYGPQ-UHFFFAOYSA-N

SMILES

CC1(C(=[N+](CCCCS([O-])(=O)=O)C2C=CC3=CC=CC=C3C1=2)C=CC=CC=CC=C1C(C2C3=CC=CC=C3C=CC=2N1CCCCS(O)(=O)=O)(C)C)C.[NaH]

LogP

-0.290

CAS DataBase Reference

3599-32-4(CAS DataBase Reference)

EPA Substance Registry System

1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt (3599-32-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

DE3150000

HS Code 

32129000

Hazardous Substances Data

3599-32-4(Hazardous Substances Data)

Toxicity

LD50 intravenous in mouse: 60mg/kg

MSDS

• Language:English Provider:Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Indocyanine green Usage And Synthesis

Description

Indocyanine Green (aka ICG, IC Green, Foxgreen) is used for reliable imaging and flow cytometry. This dye is water-soluble and pH-insensitive. The fluorescence of Indocyanine Green is not visible to the human eye but is readily detected by most imaging systems.

Indocyanine Green binds tightly to plasma proteins and becomes confined to the vascular system. The dye has a half-life of 150 to 180 sec and is removed from circulation exclusively by the liver to bile juice.

Indocyanine Green is used for detection of hepatocyte-like cells, determining cardiac output, hepatic function, liver and gastric blood flow, and for ophthalmic angiography.

Chemical Properties

green to brown crystals or crystalline powder

Uses

In infrared photography; in preparation of Wratten filters.

Uses

A tricarbocyanine type of dye with infrared absorbing properties. Diagnostic aid (blood volume determination, cardiac output, hepatic function). Dyes and metabolites.

brand name

IC-Green (Akorn).

Safety Profile

Poison by intravenous route. When heated to decomposition it emits very toxic fumes of SOx, Na2O, and NOx.

storage

Store at -20°C

Abs/Em Maxima

787/819 nm

Fluoresene quantum yield

0.09

Extinction Coefficient

232000

Indocyanine green(3599-32-4)Related Product Information

• 1,1,2-Trimethyl-1H-benz[e]indole
• Indole-3-carboxylic acid
• 1,1,2-TRIMETHYL-3-(4-SULFOBUTYL)-1H-BENZ[E]INDOLIUM HYDROXIDE, INNER SALT
• Indole-5-carboxylic acid
• Methyl indole-5-carboxylate
• Indole-4-carboxylic acid
• 3-Indolepropionic acid
• 3-Indoleacetonitrile
• Methyl 1H-indole-7-carboxylate
• Indole-6-carboxaldehyde
• Methyl indole-2-carboxylate
• Methyl indole-4-carboxylate
• 1H-INDOL-3-YLBORONIC ACID
• Indole-4-boronic acid
• Methyl indole-6-carboxylate
• Ethyl indole-2-carboxylate
• Indole-7-carboxaldehyde
• 1-Naphthylhydrazine hydrochloride