Basic information Safety Supplier Related

FITC - PHALLOIDIN CONJUGATE

Basic information Safety Supplier Related

FITC - PHALLOIDIN CONJUGATE Basic information

Product Name:
FITC - PHALLOIDIN CONJUGATE
Synonyms:
  • FITC - PHALLOIDIN CONJUGATE
  • PHALLOIDIN (FITC)
  • PHALLOIDIN-FITC LABELED
  • PHALLOIDIN - FLUORESCEIN ISOTHIOCYANATE CONJUGATE
  • Phalloidin, Fluorescein Isothiocyanate Labeled
MW:
0
Mol File:
Mol File
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FITC - PHALLOIDIN CONJUGATE Chemical Properties

storage temp. 
-20°C
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
36/37/39-45-36/37-28
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3

MSDS

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FITC - PHALLOIDIN CONJUGATE Usage And Synthesis

Uses

Phalloidin, Fluorescein Isothiocyanate Labeled has been used:

  • To visualize F-Actin reorganization in primary neonatal cardiomyocytes (PNCMs) and H9C2 cells (rat cardiac myoblasts) following endothelin-1 (ET-1) and angiotensin II (Ang II) treatment.
  • In immunochemistry to label microfilament.
  • In immunofluorescence analysis to stain F-actin.

General Description

Phalloidin is a phallotoxin produced by death cap mushroom Amanita phalloides. It is a cyclic peptide, which interacts with actin and this was first identified in phalloidin-poisoned rats. It is a heptapeptide, cyclic in nature, with a crosslink between tryptophan at position 6 and cysteine at position 3. The side chain of amino acid 7 (γ-δ-dihydroxyleucine) in phalloidin, is accessible to modifications, through which fluorescently labelled phalloidin compounds can be produced.

Biochem/physiol Actions

Phalloidin interacts with polymeric actin, and not oligomeric or monomeric forms. This interaction leads to highly stabilized actin filaments, which resist depolymerization and disassembly. In rats, this toxin causes death due to liver hemorrhage, and cells show abnormal actin clustering. The affinity of phalloidin to actin is not significantly altered after derivatizing fluorescently labelled phalloidin compounds. These compounds can be used to study actin structure and organization within eukaryotic cells.

FITC - PHALLOIDIN CONJUGATESupplier

Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
Absin Bioscience Inc.
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021-38015121 15000105423
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chenjw@absin.cn
JiangSu Star Science Co.,Ltd
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400-605-7200 17312445705
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sales022@b2star.com
Beijing Boorsen Biotechnology Co., Ltd
Tel
400-901-9800 18611424007
Email
cis@bioss.com.cn
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FITC - PHALLOIDIN CONJUGATE()Related Product Information