Protein degrader 1 (TFA)
Protein degrader 1 (TFA) Basic information
- Product Name:
- Protein degrader 1 (TFA)
- Synonyms:
-
- Protein degrader 1 (TFA)
- E3 ligase Ligand 6
- VHL ligand 1 (TFA)
- (S,R,S)-AHPC TFA
- VH032-NH2 TFA
- (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
- S)-AHPC TFA
- VH032-NH2,Inhibitor,inhibit,E3 ligase-recruiting Moiety,Ligands for E3 Ligase,(S,R,S)-AHPC,(S,R,S)AHPC TFA,VHL ligand 1,VHL ligand1,VHL ligand-1,(S,R,S) AHPC TFA
- CAS:
- 1631137-51-3
- MF:
- C24H31F3N4O5S
- MW:
- 544.59
- Mol File:
- 1631137-51-3.mol
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Protein degrader 1 (TFA) Usage And Synthesis
Description
VHL-7526, also known as Protein degrader 1, is a protein degrader and is a small molecule ligand for VHL
Uses
(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
IC 50
VHL
References
[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442
Protein degrader 1 (TFA)Supplier
Daicel Chiral Technologies (China)CO.,LTD
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- 021-50460086-9 15921403865
- han_yajun@dctc.daicel.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
Jilin Province Woda Biotechnology Co., Ltd.
- Tel
- 13504435624
- 1927928688@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
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Protein degrader 1 (TFA)(1631137-51-3)Related Product Information
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