ANTI-E2F-4
ANTI-E2F-4 Basic information
- Product Name:
- ANTI-E2F-4
- Synonyms:
-
- ANTI-E2F-4
- ANTI-E2F4 (AB-1), HUMAN
- ANTI-E2F4 (AB-2), HUMAN
- ANTI-E2F4 (AB-2) MOUSE MAB
- ANTI-E2F4 MOUSE
- Monoclonal Anti-E2F4 antibody produced in mouse
- Anti-E2F transcription factor 4, p107/p130-binding
- E2F-4
- MW:
- 0
- Product Categories:
-
- Alphabetical Index
- Antibodies for Gene Regulation and Expression
- Antibodies to Transcription FactorsAntibodies
- Cell Biology
- Clone Index
- EAntibodies
- W
- Mol File:
- Mol File
ANTI-E2F-4 Chemical Properties
- storage temp.
- −20°C
- form
- buffered aqueous solution
MSDS
- Language:English Provider:SigmaAldrich
ANTI-E2F-4 Usage And Synthesis
Uses
Rabbit Anti-E2F4 antibody can be used for western blot (2.0μg/ml) and IHC (4-8μg/ml) applications.
General Description
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. (provided by RefSeq)
Biochem/physiol Actions
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.