Basic information Safety Supplier Related

AZD-7648

Basic information Safety Supplier Related

AZD-7648 Basic information

Product Name:
AZD-7648
Synonyms:
  • CPD2810
  • AZD-7648
  • AZD-7648;AZD 7648;AZD7648
  • 7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one
  • AZD7640
  • 8H-Purin-8-one, 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-
  • 7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one
  • DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinositide 3-kinase,AZD-7648,Ataxia telangiectasia mutated,antitumor,ATM and RAD3 related,ATM/ATR,AZD 7648,DNA-PK
CAS:
2230820-11-6
MF:
C18H20N8O2
MW:
380.4
Product Categories:
  • APIs
  • api
Mol File:
2230820-11-6.mol
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AZD-7648 Chemical Properties

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C)
form 
A crystalline solid
pka
3.53±0.20(Predicted)
color 
Off-white to light yellow
InChI
InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
InChIKey
XISVSTPEXYIKJL-UHFFFAOYSA-N
SMILES
N1(C)C2C(=NC(NC3=CN4N=CN=C4C=C3C)=NC=2)N(C2CCOCC2)C1=O
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AZD-7648 Usage And Synthesis

Uses

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity in non small cell lung cancer.

in vivo

AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression[1].

Animal Model:Nude mice, A549 xenografts and NCI-H1299 xenografts[1]
Dosage:100 mg/kg
Administration:Oral administration, once daily for 5 days
Result:Induced tumour growth inhibition in combination with IR in A549 xenografts and induced tumour regression in combination with IR in NCI-H1299 xenografts.

IC 50

PI3Kγ: 1.37 μM (IC50); ATM: 17.93 μM (IC50); DNA-PKcs: 91.3 nM (IC50)

storage

Store at -20°C

AZD-7648Supplier

Fujian boshi pharmaceutical technology co. LTD Gold
Tel
0595-22008920; 18120708884
Email
393612455@qq.com
ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Wuhan Luohua Medical Technology Co.,Ltd.
Tel
13477084141; 13477084141
Email
sales@luohuapharm.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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AZD-7648(2230820-11-6)Related Product Information