TM-25659
TM-25659 Basic information
- Product Name:
- TM-25659
- Synonyms:
-
- TM-25659
- 3H-Imidazo[4,5-b]pyridine, 2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- TM 25659,TM25659
- 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine
- TM-25659, 10 mM in DMSO
- TAZ Activity Modulator, TM-25659
- CAS:
- 260553-97-7
- MF:
- C30H28N8
- MW:
- 500.6
- Mol File:
- 260553-97-7.mol
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TM-25659 Chemical Properties
- Boiling point:
- 768.0±70.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 135 mg/mL (269.68 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 4.15±0.10(Predicted)
- color
- White to off-white
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TM-25659 Usage And Synthesis
Uses
TM 25659 is a novel TAZ modulator that inhibited viability in Madin-Darby dog kidney cell and in human colorectal adenocarcinoma cell.
Biological Activity
Cell permeable: yes
in vivo
TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss in vivo and decreases weight gain in an obesity model[1].
TM-25659 has a favourable pharmacokinetic profile in rats. The plasma concentration of TM-25659 declines with an approximate t1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L×h-1×kg-1 and the volume of distribution at steady-state (1.91 L×h-1×kg-1) is larger than the volume of total body fluids[1].
| Animal Model: | C57BL6 mice (4- to 6-week-old )[1] |
| Dosage: | 50 mg/kg |
| Administration: | I.p., every other day for 2 weeks |
| Result: | Attenuated weight gain in these obese mice[1]. |
| Animal Model: | Adult male Sprague-Dawley rats[1] |
| Dosage: | 10 mg/kg |
| Administration: | I.v. (2, 10 and 30 min), oral (15 and 30 min, and 1, 2, 4 and 8 h) |
| Result: | Oral administration for 4 weeks moderately but significantly attenuated weight gain and partly restored BMD in the OVX rats[1]. |
TM-25659Supplier
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
- Tel
- 13816107857
- sales@fortunechem-sh.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Changzhou Chenhong Biotechnology Co., Ltd.
- Tel
- +86-0519-85788828 +86-13775037613
- sales@chemrenpharm.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com