Pomalidomide-PEG3-CO2H Chemical Properties

Boiling point:

757.8±60.0 °C(Predicted)

Density 

1.417±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

pka

4.28±0.10(Predicted)

Pomalidomide-PEG3-CO2H Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG₃-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

storage

Store at -20°C

Pomalidomide-PEG3-CO2H(2138440-82-9)Related Product Information

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• POMALIDOMIDE-PEG1-CO2H
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• E3 Ligase Ligand-Linker Conjugates 22
• Pomalidomide-PEG2-butyl iodide
• Pomalidomide-PEG4-azide
• Pomalidomide-PEG2-N3
• E3 ligase Ligand-Linker Conjugates 50
• Pomalidomide-PEG5-Alkyne