2-Bromo-3-fluoroanisole Chemical Properties

Boiling point:

189.2±20.0 °C(Predicted)

Density 

1.531±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

crystals

color 

Off-white

CAS DataBase Reference

446-59-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2909303890

2-Bromo-3-fluoroanisole Usage And Synthesis

Uses

2-Bromo-3-fluoroanisole is a phenyl ether compound with fluorine and bromine functional groups on the benzene ring, which can be used as an organic synthesis raw material or intermediate.

Synthesis

GENERAL METHOD: 2-Bromo-3-fluorophenol (0.1 mol) was dissolved in DMF (100 mL) and K2CO3 (0.1 mol) and iodomethane (0.1 mol) were added sequentially. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, water (400 mL) was added to dilute and the mixture was extracted with hexane. The organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered through a silica plug and concentrated under reduced pressure to give 2-bromo-3-fluoroanisole.

References

[1] European Journal of Medicinal Chemistry, 2015, vol. 89, p. 524 - 539

2-Bromo-3-fluoroanisole(446-59-3)Related Product Information

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