Cystamine dihydrochloride Chemical Properties

Melting point:

217-220 °C (dec.)(lit.)

storage temp. 

Store below +30°C.

solubility 

H2O: soluble1.0g/10 mL, clear to almost clear, colorless to almost colorless (<5.5 NTU)

form 

Crystalline Powder, Crystals or Chunks

color 

White to yellow

biological source

synthetic

Water Solubility 

soluble

Sensitive 

Hygroscopic

Merck 

14,2776

BRN 

3616850

Stability:

Stable. Incompatible with strong oxidizing agents.

InChI

InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H

InChIKey

YUFRRMZSSPQMOS-UHFFFAOYSA-N

SMILES

S(CCN)SCCN.Cl.Cl

CAS DataBase Reference

56-17-7(CAS DataBase Reference)

EPA Substance Registry System

Ethanamine, 2,2'-dithiobis-, dihydrochloride (56-17-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

37/39-26-36/37/39

WGK Germany 

3

RTECS 

KR7260000

TSCA 

TSCA listed

HazardClass 

IRRITANT

HS Code 

29309070

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

MSDS

• Language:English Provider:2,2'-Dithiodi(ethylammonium) dichloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Cystamine dihydrochloride Usage And Synthesis

Chemical Properties

white powder

Uses

hepatoprotectant, t-glutaminase inhibitor, heat shock protein promoter, caspase inhibitor

Uses

sulfhydryl modifying reagent and heparin antagonist

Uses

Cystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections. It is also used as a radiation-protective agent that interferes with sulfhydryl enzymes. Further, it serves as a heparin antagonist and sulfhydryl modifying reagent. In addition to this, it is used as an inhibitor of TGase.

Safety Profile

A poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl, SOx, and NOx. See also SULFIDES.

Synthesis

Weigh 864g of composite glue, 1620g of water, 4320g of cysteamine hydrochloride, 120 mesh powdered silica 2376g and 1620g of ammonia caseic acid, add the composite glue to water, add cysteamine hydrochloride, stir well, placed at room temperature for 2h, grinding with a colloid mill for 2 times, add silica adsorbed into solid powder, and finally add ammonia caseic acid stirred for 10min, in the container 25 ?? room temperature placed 62h material internal temperature and ambient temperature consistent, the reaction is over. The reaction product is dissolved in water and filtered, and the filtrate is purified with ethanol to obtain pure cystamine dihydrochloride. The composition of the composite glue is carboxymethyl cellulose 258g, sodium alginate 172g and xanthan gum 430g.

storage

room temperature (desiccate)

Purification Methods

Recrystallise the salt by dissolving in EtOH containing a few drops of dry EtOH/HCl, filtering and adding dry Et2O. The solid is dried in a vacuum and stored in a dry and dark atmosphere. It has been recrystallised from EtOH (solubility: 1g in 60mL of boiling EtOH) or MeOH (plates). The free base has b 90-Purification of Biochemicals — Amino Acids and Peptides 100o/0.001mm, 106-108o/5mm and 135-136o/760mm, d 4 1.1559, n D 1.5720. [Verly & Koch Biochem J 58 663 1954, Gonick et al. J Am Chem Soc 76 4671 1954, Jackson & Block J Biol Chem 113 137 1936.] The dihydrobromide has m 238-239o (from EtOH/Et2O) [Viscontini Helv Chim Acta 36 835 1953]. [Beilstein 4 H 287, 4 IV 1578.]

Cystamine dihydrochloride(56-17-7)Related Product Information

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