BIPERIDEN LACTATE
BIPERIDEN LACTATE Basic information
- Product Name:
- BIPERIDEN LACTATE
- Synonyms:
-
- lacticacid,compd.withalpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropan
- BIPERIDEN LACTATE
- lactic acid, compound with alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenylpiperidin-1-propanol (1:1)
- akinetonlactate
- alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanolcompd.withlactica
- Propanoic acid, 2-hydroxy-, compd. with α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol (1:1)
- BIPERIDEN LACTATE USP/EP/BP
- CAS:
- 7085-45-2
- MF:
- C24H35NO4
- MW:
- 401.55
- EINECS:
- 230-388-9
- Mol File:
- 7085-45-2.mol
BIPERIDEN LACTATE Chemical Properties
- Melting point:
- 97-101°C
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
BIPERIDEN LACTATE Usage And Synthesis
Uses
Anticholinergic; antiparkinsonian.
Uses
Biperiden Lactate is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
brand name
Akineton (Abbott).
in vivo
Biperiden lactate (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]. Biperiden lactate (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].
| Animal Model: | Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; everyday; 3 weeks |
| Result: | Tumor size reduced by 83%. |
| Animal Model: | Male Wistar rats (200-250 g)[2] |
| Dosage: | 8 mg/kg |
| Administration: | Intraperitoneal injection; every 8 hours; 10 days |
| Result: | Reduced late seizures by about three times with no affecting emotional memory damage |
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