Pomalidomide 4'-alkylC5-acid Chemical Properties

Boiling point:

712.2±60.0 °C(Predicted)

Density 

1.443±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

4.75±0.10(Predicted)

color 

Light yellow to yellow

Pomalidomide 4'-alkylC5-acid Usage And Synthesis

Description

Pomalidomide-C5-acid is an E3 ligase ligand-linker conjugate.

Uses

Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. Patent WO2018106870A1.

Pomalidomide 4'-alkylC5-acid(2225940-49-6)Related Product Information

• E3 ligase Ligand-Linker Conjugates 49
• Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
• Pomalidomide-C6-PEG3-butyl iodide
• POMALIDOMIDE-C9-CO2H
• Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• E3 ligase Ligand-Linker Conjugates 55
• 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
• Pomalidomide-6-2-2-6-N3
• Pomalidomide-amido-C1-Br
• Pomalidomide-C6-NH2?hydrochloride
• Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
• 4-((4-azidobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• -alkylC5-amine