4-methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid
4-methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid Basic information
- Product Name:
- 4-methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid
- Synonyms:
-
- Pentanoic acid, 4-methyl-4-(2-pyridinyldithio)-
- 4-Methyl-4-(2-pyridinyldithio)pentanoic acid
- CAS:
- 1537891-69-2
- MF:
- C11H15NO2S2
- MW:
- 257.37
- Mol File:
- 1537891-69-2.mol
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4-methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid Chemical Properties
- Boiling point:
- 416.1±41.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- pka
- 4.54±0.10(Predicted)
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4-methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid Usage And Synthesis
Uses
4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
Disulfide Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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