4-Hydroxy-2-butanone
4-Hydroxy-2-butanone Basic information
- Product Name:
- 4-Hydroxy-2-butanone
- Synonyms:
-
- H**4-HYDROXY-2-BUTANONE
- 2-Butanone, 4-hydroxy-
- 2-Butanone,4-hydroxy-
- 3-Ketobutan-1-ol
- 3-Oxo-1-butanol
- 3-Oxobutanol
- 4-Butanol-2-one
- 4-hydroxy-2-butanon
- CAS:
- 590-90-9
- MF:
- C4H8O2
- MW:
- 88.11
- EINECS:
- 209-693-6
- Product Categories:
-
- in-stock
- straight chain compounds
- ketone
- 1
- bc0001
- 590-90-9
- john's
- Mol File:
- 590-90-9.mol
4-Hydroxy-2-butanone Chemical Properties
- Melting point:
- 15°C (estimate)
- Boiling point:
- 73-76 °C/12 mmHg (lit.)
- Density
- 1.023 g/mL at 25 °C (lit.)
- refractive index
- 1.430
- Flash point:
- 91°F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Oil
- pka
- 14.43±0.10(Predicted)
- color
- Clear Colourless
- Water Solubility
- Miscible with water, alcohol, ethanol and ether.
- BRN
- 1737666
- LogP
- -1.209 at 25℃
- CAS DataBase Reference
- 590-90-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Hydroxy-2-butanone(590-90-9)
- EPA Substance Registry System
- 2-Butanone, 4-hydroxy- (590-90-9)
MSDS
- Language:English Provider:ALFA
4-Hydroxy-2-butanone Usage And Synthesis
Chemical Properties
Colourless to pale yellow liquid
Uses
4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones.
Application
4-Hydroxy-2-butanone has been used in the synthesis of:
- 3-buten-2-one via dehydration over anatase-TiO2 catalyst
- 4-methyl-5-hydroxymethylthiazole
- (±)-lineatin
- mevalonic acid lactone
- verrucarin
- β-hydroxylactones
Definition
ChEBI: A beta-hydroxy ketone that is butan-2-one substituted by a hydroxy group at position 4.
General Description
4-Hydroxy-2-butanone is an important pharmaceutical intermediate. Gas phase reaction of the OH radicals with 4-hydroxy-2-butanone has been investigated by absolute rate method.
4-Hydroxy-2-butanone Preparation Products And Raw materials
Raw materials
Preparation Products
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