4-Hydroxy-2-butanone Chemical Properties

Melting point:

15°C (estimate)

Boiling point:

73-76 °C/12 mmHg (lit.)

Density 

1.023 g/mL at 25 °C (lit.)

refractive index 

1.430

Flash point:

91°F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform, Methanol (Slightly)

pka

14.43±0.10(Predicted)

form 

Oil

color 

Clear Colourless

Water Solubility 

Miscible with water, alcohol, ethanol and ether.

BRN 

1737666

LogP

-1.209 at 25℃

CAS DataBase Reference

590-90-9(CAS DataBase Reference)

NIST Chemistry Reference

4-Hydroxy-2-butanone(590-90-9)

EPA Substance Registry System

2-Butanone, 4-hydroxy- (590-90-9)

Safety Information

Risk Statements 

10

Safety Statements 

16-24/25

RIDADR 

UN 1993

WGK Germany 

3

TSCA 

Yes

HS Code 

29144000

MSDS

• Language:English Provider:ALFA

4-Hydroxy-2-butanone Usage And Synthesis

Chemical Properties

Colourless to pale yellow liquid

Uses

4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones.

Application

4-Hydroxy-2-butanone has been used in the synthesis of:

• 3-buten-2-one via dehydration over anatase-TiO2 catalyst
• 4-methyl-5-hydroxymethylthiazole
• (±)-lineatin
• mevalonic acid lactone
• verrucarin
• β-hydroxylactones

Definition

ChEBI: A beta-hydroxy ketone that is butan-2-one substituted by a hydroxy group at position 4.

General Description

4-Hydroxy-2-butanone is an important pharmaceutical intermediate. Gas phase reaction of the OH radicals with 4-hydroxy-2-butanone has been investigated by absolute rate method.

4-Hydroxy-2-butanone(590-90-9)Related Product Information

• Methylparaben
• Kresoxim-methyl
• CHLOROPHOSPHONAZO III
• Bensulfuron methyl
• 4-Cyanophenol
• 2-Butanone oxime
• Methyl acrylate
• 2-(METHYLSULFONYL)ETHANOL
• 4-Methyl-2-pentanone
• Methyl
• Parathion-methyl
• Acetoin
• 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Methyl 4-chloro-3-oxo-butanoate
• Ethyl 4,4,4-trifluoroacetoacetate
• Ethyl 2-oxocyclopentanecarboxylate
• Ethyl 2-oxocyclohexanecarboxylate
• Mordant Blue 29