NVP-AAM077 Chemical Properties

Density 

1.639±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble10mg/mL, clear

form 

White solid

pka

1.19±0.10(Predicted)

color 

white to beige

Water Solubility 

Soluble in water (10mM)

InChIKey

AJYMYLQKBICSOD-ULMLUZALSA-J

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

NVP-AAM077 Usage And Synthesis

Uses

PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice.

Biochem/physiol Actions

PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.

Enzyme inhibitor

This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate.

storage

-20°C

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