SR 12813 Chemical Properties

Melting point:

119-121℃

Boiling point:

552.6±50.0 °C(Predicted)

Density 

1.117±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: ≥10 mg/mL

form 

solid

pka

9.95±0.70(Predicted)

Safety Information

WGK Germany 

3

HS Code 

29319090

SR 12813 Usage And Synthesis

Uses

SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.

Definition

ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).

Biological Activity

Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

Biochem/physiol Actions

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.

storage

Store at +4°C

SR 12813(126411-39-0)Related Product Information

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