Basic information Safety Supplier Related

SR 12813

Basic information Safety Supplier Related

SR 12813 Basic information

Product Name:
SR 12813
Synonyms:
  • SR-12813(GW 485801)
  • SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801
  • GW 485801
  • GW485801
  • GW-485801
  • [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester
  • SR12813;SR 12813
  • Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester
CAS:
126411-39-0
MF:
C24H42O7P2
MW:
504.53
Mol File:
126411-39-0.mol
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SR 12813 Chemical Properties

Melting point:
119-121℃
Boiling point:
552.6±50.0 °C(Predicted)
Density 
1.117±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: ≥10 mg/mL
form 
solid
pka
9.95±0.70(Predicted)
color 
White to off-white
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Safety Information

WGK Germany 
3
HS Code 
29319090
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SR 12813 Usage And Synthesis

Uses

SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.

Definition

ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).

Biological Activity

Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

Biochem/physiol Actions

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.

storage

Store at +4°C

SR 12813Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Mashilabs (Shanghai) Co.,Ltd.
Tel
19916721580
Email
mafarm@126.com