NONAETHYLENE GLYCOL MONODODECYL ETHER Chemical Properties

Melting point:

33-36 °C

Boiling point:

615.9±50.0 °C(Predicted)

Density 

1.007±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

n20/D 1.459

Flash point:

244℃ (Cleveland open test)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Gel

pka

14.36±0.10(Predicted)

color 

White to Off-White

Odor

at 100.00?%. bland

PH

pH (50g/l, 25℃) : 4.0～6.0

BRN 

1895308

InChI

InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3

InChIKey

ONJQDTZCDSESIW-UHFFFAOYSA-N

SMILES

C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCCCCCCCCCCC

LogP

3.029 (est)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

NONAETHYLENE GLYCOL MONODODECYL ETHER Usage And Synthesis

Uses

Nonaethylene Glycol Monododecyl Ether is a nonionic surfactant useful in the formation of emulsions.

Definition

ChEBI: Polidocanol is a hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group. It has a role as a nonionic surfactant, a hepatotoxic agent and a sclerotherapy agent. It is functionally related to a nonaethylene glycol.

Application

Nonaethylene glycol monododecyl ether has been used in a study to assess a procedure for analyzing total lipid and triacylglycerol using bovine liver tissue. It has also been used in a study to investigate how particle size of aggregates can be measured by the concentration dependence of the amplitude of the autocorrelation function.

General Description

Nonaethylene glycol monododecyl ether [C12H25O(CH2CH2O)9H] (AEO9) is a non-ionic surfactant.

Mechanism of action

Nonaethylene Glycol Monododecyl Ether locally damages the endothelium of blood vessels. Following endothelial damage, platelets accumulate at the site and attach to the vein wall, eventually forming a dense network of platelets, cellular debris and fibrin that clogs the vessel. Eventually, the blood vessel is replaced by connective fibrous tissue.

Synthesis

Nonaethylene glycol monododecyl ether is prepared by the reaction of oxirane and 1-Dodecanol. The specific synthesis steps are as follows:
General procedure: Ethoxylated fatty alcohols (C8,10,12) were producing using asemi-micro apparatus with a K10 clay catalyst at 40-50 ℃ The EO was added to the reactor (freefrom oxygen) containing 0.1 mol fatty alcohols and about0.2-0.55 wt% catalyst to give the desired average degree ofethoxylation (5, 7 and 9 mol of ethylene oxide). The EO uptake (average degree of ethoxylation)was determined from the increasing weight of thereaction mixture and confirmed by IR and 1HNMR.

NONAETHYLENE GLYCOL MONODODECYL ETHER(3055-99-0)Related Product Information

• LAURETH-5 CARBOXYLIC ACID
• C12E5
• LAURETH-4 PHOSPHATE
• HEXAETHYLENE GLYCOL MONODODECYL ETHER
• LAURETH-6 CITRATE
• C12E8
• HEPTAETHYLENE GLYCOL MONODODECYL ETHER
• LAURETH-7 CITRATE
• LAURETH-8 CARBOXYLIC ACID
• LAURETH-7 TARTRATE
• SODIUM LAURETH-7 TARTRATE
• LAURETH-50
• MEA-LAURETH-6 CARBOXYLATE
• POTASSIUM LAURETH-5 CARBOXYLATE
• LAURETH-5 BUTYL ETHER
• LAURETH-6 CARBOXYLIC ACID
• POTASSIUM LAURETH-6 CARBOXYLATE
• PHENYLSELENOL