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CARBOXYMETHYLCELLULOSE CALCIUM

Basic information Safety Supplier Related

CARBOXYMETHYLCELLULOSE CALCIUM Basic information

Product Name:
CARBOXYMETHYLCELLULOSE CALCIUM
Synonyms:
  • Cellulose,ethers,carboxymethyl ether,calcium salt
  • N4-(2-Chloro-7-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine
  • hylon600
  • CMCCalcium
  • CALCIUMCARBOXYLMETHYLCELLULOSE
  • Calciam carboxymethylceUulose
  • Carboxymethylcellulose calcium (nf)
  • Carmellose calcium (jp15)
CAS:
9050-04-8
MF:
C23H30ClN3O
MW:
399.9568
EINECS:
618-597-7
Mol File:
9050-04-8.mol
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CARBOXYMETHYLCELLULOSE CALCIUM Chemical Properties

solubility 
Practically insoluble in acetone, chloroform, ethanol (95%), toluene, and ether. Insoluble in water, but swells to form a suspension.
EPA Substance Registry System
Cellulose, carboxymethyl ether, calcium salt (9050-04-8)
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Safety Information

HS Code 
3912310000
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CARBOXYMETHYLCELLULOSE CALCIUM Usage And Synthesis

Chemical Properties

DS 0.5-0.7

Chemical Properties

Carboxymethylcellulose calcium occurs as a white to yellowishwhite, hygroscopic, odorless powder.

Uses

Pharmaceutic aid (tablet disintegrant).

Production Methods

Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated, followed by conversion to the calcium salt. It is then graded on the basis of its degree of carboxymethylation and pulverized.

Pharmaceutical Applications

The main use of carboxymethylcellulose calcium is in tablet formulations, where it is used as a binder, diluent, and disintegrant. Although carboxymethylcellulose calcium is insoluble in water, it is an effective tablet disintegrant as it swells to several times its original bulk on contact with water. Concentrations up to 15% w/w may be used in tablet formulations; above this concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications similarly to carboxymethylcellulose sodium; for example, as a suspending or viscosity-increasing agent in oral and topical pharmaceutical formulations. Carboxymethylcellulose calcium is also used in modern wound dressings for its water absorption, retention and hemostatic properties.

Safety

Carboxymethylcellulose calcium is used in oral and topical pharmaceutical formulations, similarly to carboxymethylcellulose sodium, and is generally regarded as a nontoxic and nonirritant material. However, as with other cellulose derivatives, oral consumption of large amounts of carboxymethylcellulose calcium may have a laxative effect.

storage

Carboxymethylcellulose calcium is a stable, though hygroscopic material. It should be stored in a well-closed container in a cool, dry place.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral, capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

CARBOXYMETHYLCELLULOSE CALCIUM Preparation Products And Raw materials

Raw materials

CARBOXYMETHYLCELLULOSE CALCIUMSupplier

Spectrum Chemical Manufacturing Corp. Gold
Tel
021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Email
shenlinxing@macklin.cn
Alfa Chemistry
Tel
1-516-6625404
Email
support@alfa-chemistry.com
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com