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Trifluoroacetamidine

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Trifluoroacetamidine Basic information

Product Name:
Trifluoroacetamidine
Synonyms:
  • trifluoroethanimidamide
  • Trifluoroacetamidine
  • Trifluoroacetamideine
  • 2,2,2-Trifluoroethanimidamide
  • EthaniMidaMide, 2,2,2-trifluoro-
  • 2,2,2-trifluoroacetiMidaMide
  • TRIFLUOROACETAMIDINE, TECH.
  • uoroacetamidine
CAS:
354-37-0
MF:
C2H3F3N2
MW:
112.05
EINECS:
670-531-6
Product Categories:
  • Fluorochemicals
Mol File:
354-37-0.mol
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Trifluoroacetamidine Chemical Properties

Boiling point:
35-37°C 11mm
Density 
1.45
refractive index 
1.3801
Flash point:
35-37°C/11mm
storage temp. 
Store below -20C
pka
6.07±0.40(Predicted)
form 
liquid
color 
Clear, yellow
Water Solubility 
Fully miscible in water.
Sensitive 
Moisture Sensitive
BRN 
605978
InChI
InChI=1S/C2H3F3N2/c3-2(4,5)1(6)7/h(H3,6,7)
InChIKey
NITMACBPVVUGOJ-UHFFFAOYSA-N
SMILES
C(N)(=N)C(F)(F)F
CAS DataBase Reference
354-37-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C,Xi
Risk Statements 
34
Safety Statements 
26-36/37/39-45-20
RIDADR 
3267
Hazard Note 
Corrosive/Irritant
HazardClass 
8
PackingGroup 
II
HS Code 
29252900

MSDS

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Trifluoroacetamidine Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Trifluoroacetamidine is used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies. It is a reagent used as protected ammonia equivalent.

Synthesis

Trifluoroacetamidine is a vital chemical intermediate with a wide range of applications. A preparation method comprises the following steps: trifluoroacetamide is used as raw materials, polyphosphoric acid is selected as solvents under the effect of phosphorus pentoxide as dehydrating agents, and trifluoroacetonitrile can be fast prepared through a dehydration reaction. The generated trifluoroacetonitrile gas is introduced into a liquid ammonia kettle after being cooled, and the trifluoroacetamidine can be prepared.

Trifluoroacetamidine Preparation Products And Raw materials

Raw materials

AmmoniaTrifluoroacetonitrile

Preparation Products

Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE2-(TRIFLUOROMETHYL)PYRIMIDIN-5-AMINE(2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL)METHANOL(2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL)METHANAMINE2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONYL CHLORIDE2-(TRIFLUOROMETHYL)PYRIMIDIN-4-AMINE2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXAMIDEETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID4-CHLORO-2,6-BIS(TRIFLUOROMETHYL)PYRIMIDINE4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID5-(AMINOMETHYL)-2-(TRIFLUOROMETHYL)PYRIMIDIN-4-AMINE4-Hydroxy-2-(trifluoromethyl)pyrimidine4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID

TrifluoroacetamidineSupplier

LEWOO PHARMATECH (SHANGHAI) CO.,LTD Gold
Tel
15800805830
Email
miao@lewoopharma.com.cn
Yangzhou modier Electronic Materials Co., Ltd Gold
Tel
0514-82098883; 13761402923
Email
market@modeltemol.com
Hunan Furui Biopharma Technology Co., Ltd. Gold
Tel
15902102743
Email
shelley@furuipharma.com
Hubei Kanglide Bio-pharmaceutical Co., Ltd Gold
Tel
19171595131
Email
3168392538@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
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