WITHANOLIDE A(P) Chemical Properties

Melting point:

305℃ (DEC.)

Boiling point:

651.6±55.0 °C(Predicted)

Density 

1.264

storage temp. 

-20°C

solubility 

methanol: soluble1mg/mL, clear, colorless

form 

powder

pka

13.05±0.70(Predicted)

color 

white

Safety Information

WGK Germany 

3

HS Code 

2932206000

WITHANOLIDE A(P) Usage And Synthesis

Uses

Withanolide A, is a neuritogenic steroid. It may act as deterrent for feeding insect larva and other herbivores. Withaferin A, causes activation of Notch2 and Notch4 in human breast cancer cells, and thus used as novel anticancer agents.

Definition

ChEBI: Withanolide A is a withanolide.

Biological Activity

C28-steroidal lactone th at can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer′s and Parkinson′s disease. In primary r at cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimerμs-inflicted brain.

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