ANISODAMINE HYDROBROMIDE CAS#: 55449-49-5

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ANISODAMINE HYDROBROMIDE

Basic information Safety Supplier Related

ANISODAMINE HYDROBROMIDE Basic information

Product Name:

ANISODAMINE HYDROBROMIDE

Synonyms:

ANISODAMINE HYDROBROMIDE
ANISODAMINE HYDROBROMIDE USP/EP/BP
Anisodamine HBr
Anisodamine hydrobromide-RM

CAS:

55449-49-5

MF:

C7H10BrNO

MW:

204.0644

Mol File:

55449-49-5.mol

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ANISODAMINE HYDROBROMIDE Chemical Properties

Melting point:: 176-178 °C
form: Solid
color: White to off-white

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ANISODAMINE HYDROBROMIDE Usage And Synthesis

Uses

Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2].

in vivo

Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%^[2].

Animal Model:	LPS-Induced Shock Mice^[2]
Dosage:	50 mg/kg
Administration:	I.p.
Result:	Markedly decreased the mortality to 20%.

References

[1] Eisenkraft A. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016;173(11):1719-1727. DOI:10.1111/bph.13486
[2] Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641. DOI:10.1097/CCM.0b013e31819598f5

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