5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE
5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Basic information
- Product Name:
- 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE
- Synonyms:
-
- 5'-Isobutylthioadenosine
- 5'-ISOBUTYLTHIOADENOSINE;5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE
- 5'-Deoxy-5'-isobutylthioadenosine
- 5’-deoxy-5’-s-isobutylthioadenosine
- 5'-S-(2-Methylpropyl)-5'-thioadenosine
- SIBA
- 5'-S-Isobutyl-5'-deoxyadenosine
- 5'-S-Isobutylthioadenosine
- CAS:
- 35899-54-8
- MF:
- C14H21N5O3S
- MW:
- 339.41
- Mol File:
- 35899-54-8.mol
5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Chemical Properties
- Boiling point:
- 631.2±65.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO : ≥ 100 mg/mL (294.63 mM)
- pka
- 13.13±0.70(Predicted)
- form
- Solid
- color
- Off-white to gray
5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Usage And Synthesis
Uses
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH.html" class="link-product" target="_blank">SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].
in vivo
SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo[1].
SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo[1].
| Animal Model: | C57BL/6 female mice (4-8 weeks old)[1]. |
| Dosage: | 150 mg/kg |
| Administration: | Intraperitoneal injection; twice weekly for 3 weeks. |
| Result: | Significantly reduced the median number of lung metastases. |
| Animal Model: | Adult syngeneic Wistar AG rats (8-week-old; subcutaneously grafted with RMS-J1 cells)[1]. |
| Dosage: | 15 mg/kg |
| Administration: | Intraperitoneal injection; thrice weekly for 4 weeks. |
| Result: | Inhibited in vivo metastatic spread of RMS-J1 cells, and showed median numbers of lung metastatic nodules was 26. |
IC 50
Plasmodium; HSV-1
References
[1] F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. DOI:10.1007/BF01580402
[2] B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. DOI:10.1128/JVI.22.1.160-167.1977
[3] Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9. DOI:10.1042/bj2040853
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5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE(35899-54-8)Related Product Information
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