NU7026 Chemical Properties

Melting point:

267-269 °C(Solv: methanol (67-56-1); water (7732-18-5))

Boiling point:

459.9±45.0 °C(Predicted)

Density 

1.330

storage temp. 

2-8°C

solubility 

DMSO: 3 mg/mL at 60 °C, soluble

form 

solid

pka

0.49±0.20(Predicted)

color 

tan

Safety Information

WGK Germany 

3

NU7026 Usage And Synthesis

Uses

DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK.

Uses

NU7026 has been used:

• as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
• in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
• to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Definition

ChEBI: 2-(4-morpholinyl)-4-benzo[h][1]benzopyranone is an organooxygen compound and an organic heterotricyclic compound.

Biological Activity

ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

storage

Store at +4°C

NU7026(154447-35-5)Related Product Information

• Imidazolidinyl urea
• NU7441 (KU-57788)
• KU-55933 (ATM Kinase Inhibitor)
• VE-821
• KU-60019
• ABT 737
• Olaparib
• NU7026
• 4H-1-Benzopyran-4-one, 2-(diethylamino)-