GATIFLOXACIN MESYLATE
GATIFLOXACIN MESYLATE Basic information
- Product Name:
- GATIFLOXACIN MESYLATE
- Synonyms:
-
- AM 1155 mesylate
- AM 1155 MESYLATE;BMS 206584-01 MESYLATE;PD 135432 MESYLATE
- BMS 206584-01 mesylate
- Gatifloxacin mesylate (AM 1155 mesylate
- PD 135432 mesylate)
- GATIFLOXACIN MESYLATE
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-, MonoMethanesulfonate (9CI)
- GATIFLOXACIN MESYLATE USP/EP/BP
- CAS:
- 316819-28-0
- MF:
- C19H22FN3O4.CH4O3S
- MW:
- 471.503
- Mol File:
- 316819-28-0.mol
GATIFLOXACIN MESYLATE Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- InChIKey
- PMMNVFFMFJMFDB-UHFFFAOYSA-N
- SMILES
- S(=O)(=O)(O)C.C1(=C(N2CC(C)NCC2)C(OC)=C2N(C3CC3)C=C(C(=O)C2=C1)C(=O)O)F
GATIFLOXACIN MESYLATE Usage And Synthesis
Uses
Gatifloxacin mesylate is a fourth generation fluoroquinolone antibiotic with broad-spectrum antibacterial activity. It is able to inhibit bacterial type II topoisomerase (IC50 = 13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA rotamase (IC50 = 0.109 μg/ml). It can be used to treat bacterial conjunctivitis in vivo, and its injection can treat acute urinary tract infections with efficacy comparable to levofloxacin hydrochloride injection[1].
in vivo
Gatifloxacin mesylate (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis[4].
| Animal Model: | Female BALB/c mice with Nocardia brasiliensis in the right hind footpad. |
| Dosage: | 100 mg/kg |
| Administration: | Subcutaneous injection; 3 times a day; 30 days |
| Result: | Reduced the production of lesions in mice. |
IC 50
Quinolone; Topoisomerase II: 36.7 μM (IC50)
References
[1] L. DENG. Observation on the curative effect of gatifloxacin mesylate injection in the treatment of acute urinary tract infections[J]. International Medical and Health Herald, 2009. DOI:10.3760/CMA.J.ISSN.1007-1245.2009.05.025.
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