ACO2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Aconitase 2 catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid cycle. ACO2 is also an important regulator of iron homeostasis within cells. In addition, research studies have shown that this enzyme is deficient in the mitochondrial disease Friedreich's Ataxia.

References

[1] Gille, G. and Reichmann, H. (2011) J Neural Transm 118, 349-59.
[2] Mirel, D.B. et al. (1998) Gene 213, 205-18.
[3] Myers, C.R. et al. (2010) Free Radic Biol Med 49, 1903-15.
[4] Rötig, A. et al. (1997) Nat Genet 17, 215-7.
[5] Ye, H. and Rouault, T.A. (2010) Biochemistry 49, 4945-56.

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