CHGA antibody Usage And Synthesis

Source

Rabbit

Applications

CHGA antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Recommended dilution range for Western blot is 1:500 ~ 1:1,000 and immunohistochemistry analysis is 1:100~200. Recommended starti

Reactivity

Human

Immunogen

Anti-human CHGA mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CHGA amino acids 19-131 purified from E. coli.

Background

Chromgranin-A is part of the neuroendocrine secretory protein family. CHGA is located in secretory vesicles of neurons and endocrine cells. Chromgranin-A is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. Chromgranin-A has numerous biological activities on some tissues and organs and exerts a large spectrum of homeostatic actions, including antifungal and antimicrobial effect, modulation of cell adhesion, and inhibition of parathyroid hormone secretion.

References

[1] Machado, J.D. et al. (2010) Cell Mol Neurobiol 30, 1181-7.
[2] Dominguez, N. et al. (2018) J Neurochem 144, 241-54.
[3] Weisbrod, A.B. et al. (2013) Horm Cancer 4, 165-75.
[4] Annaratone, L. et al. (2014) Endocr Pathol 25, 219-28.
[5] Ardill, J.E. and Erikkson, B. (2003) Endocr Relat Cancer 10, 459-62.
[6] Welin, S. et al. (2009) Neuroendocrinology 89, 302-7.

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