HLTF antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Monkey

Background

Helicase-like transcription factor, also known as RUSH-1 or SMARCA3, belongs to the SNF2/SWI2 family of ATP-dependent remodelers. HLTF has been shown to interact with ubiquitin enzyme complexes to promote Lys-63-linked polyubiquitination of PCNA, maintaining genomic stability during DNA damage. HLTF has double-stranded DNA translocation activity, which can restart replication forks at DNA lesions, providing tumor suppressive functions. The HLTF gene is frequently hypermethylated in many different tumor types.

References

[1] Sheridan, P.L. et al. (1995) J Biol Chem 270, 4575-87.
[2] Ding, H. et al. (1996) DNA Cell Biol 15, 429-42.
[3] Hayward-Lester, A. et al. (1996) Mol Endocrinol 10, 1335-49.
[4] Unk, I. et al. (2008) Proc Natl Acad Sci U S A 105, 3768-73.
[5] Motegi, A. et al. (2008) Proc Natl Acad Sci U S A 105, 12411-6.
[6] Blastyák, A. et al. (2010) Mol Cell Biol 30, 684-93.
[7] Moinova, H.R. et al. (2002) Proc Natl Acad Sci U S A 99, 4562-7.
[8] Hibi, K. et al. (2003) Int J Cancer 104, 433-6.
[9] Leung, W.K. et al. (2003) Mol Carcinog 37, 91-7.

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