MIB1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Mindbomb homolog 1 is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged. MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase in vitro. Expression of MIB1 is seen in both adult and embryonic murine tissues. Recently, MIB1 was reported to regulate the extrinsic cell death pathway by binding to cellular FLICE-like inhibitory proteins, which reduces the interaction of caspase-8 with cFLIP and leads to cell death. MIB1 is also involved in T and marginal zone B cell development in the lymphopoietic niches.

References

[1] Koo, B.K. et al. (2005) Development 132, 3459-70.
[2] Matsuda, M. and Chitnis, A.B. (2009) Development 136, 197-206.
[3] Zhang, L. et al. (2007) J Biol Chem 282, 11795-804.
[4] Jin, Y. et al. (2002) J Biol Chem 277, 46980-6.
[5] Zhang, L. and Gallagher, P.J. (2009) Am J Physiol Cell Physiol 297, C1275-83.
[6] Song, R. et al. (2008) J Exp Med 205, 2525-36.

MIB1 antibody()Related Product Information

• IDH1 antibody
• Mouse Monoclonal DAPP1 Antibody
• Anti-CD5
• Rabbit Polyclonal FETUB Antibody
• TMPRSS2 antibody
• RASA4 antibody
• GH1 Antibody
• Rabbit Polyclonal HOXC10 Antibody
• GLP2R Antibody
• ST14 antibody