PIM1 Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Pim proteins are oncogene-encoded serine/threonine kinases. Pim-1, a serine/threonine kinase highly expressed in hematopoietic cells, plays a critical role in the transduction of mitogenic signals and is rapidly induced by a variety of growth factors and cytokines. Pim-1 cooperates with c-Myc in lymphoid cell transformation and protects cells from growth factor withdrawal and genotoxic stress-induced apoptosis. Pim-1 also enhances the transcriptional activity of c-Myb through direct phosphorylation within the c-Myb DNA binding domain as well as phosphorylation of the transcriptional coactivator p100. Hypermutations of the Pim-1 gene are found in B-cell diffuse large cell lymphomas. Phosphorylation of Pim-1 at Tyr218 by Etk occurs following IL-6 stimulation and correlates with an increase in Pim-1 activity. Various Pim substrates have been identified; Bad is phosphorylated by both Pim-1 and Pim-2 at Ser112 and this phosphorylation reverses Bad-induced cell apoptosis.The corresponding pim-1 gene encodes a pair of proteins through use of different translation initiation sites. Both larger 44 kDa and smaller 33 kDa proteins are active kinases, but differ in stability.

References

[1] Mikkers, H. et al. (2004) Mol Cell Biol 24, 6104-15.
[2] Selten, G. et al. (1986) Cell 46, 603-11.
[3] Meeker, T.C. et al. (1987) J Cell Biochem 35, 105-12.
[4] Dautry, F. et al. (1988) J Biol Chem 263, 17615-20.
[5] Möröy, T. et al. (1993) Proc Natl Acad Sci USA 90, 10734-8.
[6] Lilly, M. and Kraft, A. (1997) Cancer Res 57, 5348-55.
[7] Leverson, J.D. et al. (1998) Mol Cell 2, 417-25.
[8] Winn, L.M. et al. (2003) Cell Cycle 2, 258-62.
[9] Pasqualucci, L. et al. (2001) Nature 412, 341-6.
[10] Kim, O. et al. (2004) Oncogene 23, 1838-44.

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