TNFRSF10C Antibody Usage And Synthesis

Applications

The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity.

Immunogen

Anti-human TNFRSF10C mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human TNFRSF10C amino acids 26-236 purified from E. coli.

Background

TRAIL Receptor-3, also known as TNFRSF10C belongs to the TNF-receptor super family. TNFRSF10C contains an extracellular TRAIL-binding domain as well as a transmembrane domain, however no cytoplasmic death domain. Furthermore, TNFRSF10C is not capable of inducing apoptosis, and is considered to act as an antagonistic receptor which protects cells from TRAIL-induced apoptosis.

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