CHMP4B Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

CHMP4B, the human homologue of yeast Snf7, interacts with Alix and is a core component of the ESCRT-III complex. The ESCRT system is comprised of multiple protein complexes denoted as ESCRT-0, -I, -II, -III, and VPS4 ATPase that together contribute to a number of membrane fission events, including multivesicular body and exosome formulation, viral budding, abscission during cytokinesis, and plasma membrane repair. Interestingly, it was found that the ESCRT-III complex, including CHMP4B is recruited to the plasma membrane during the regulated process of necrosis, necroptosis, and thereby controls membrane integrity sustaining these cells and allowing continued signaling and cytokine/chemokine secretion. Elevated expression of CHMP4B has been associated with neuronal apoptosis following intracerebral hemorrhage. In addition, high CHMP4B expression was associated with increased proliferation and resistance to doxorubicin in hepatocellular carcinoma.

References

[1] Katoh, K. et al. (2003) J Biol Chem 278, 39104-13.
[2] McCullough, J. et al. (2008) Proc Natl Acad Sci U S A 105, 7687-91.
[3] Henne, W.M. et al. (2013) Cold Spring Harb Perspect Biol 5(9): a016766.
[4] McCullough, J. et al. (2013) Annu Rev Biochem 82, 663-92.
[5] Gong, Y.N. et al. (2017) Cell 169, 286-300.e16.
[6] Shen, J. et al. (2015) Brain Res 1597, 1-13.
[7] Hu, B. et al. (2015) Tumour Biol 36, 2569-81.

CHMP4B Antibody()Related Product Information

• GPHN antibody
• VDAC2 antibody
• RETN antibody
• RAB6C antibody
• Rabbit Polyclonal SLC17A7 Antibody
• KCNA7 antibody
• CTBP2 antibody
• PSTPIP1 antibody
• Rabbit Polyclonal SLC17A6 Antibody
• AGTR1 antibody