Mc-Val-Cit-PAB-Cl
Mc-Val-Cit-PAB-Cl Basic information
- Product Name:
- Mc-Val-Cit-PAB-Cl
- Synonyms:
-
- Mc-Val-Cit-PAB-Cl
- L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(chloromethyl)phenyl]-
- Mc Val Cit PAB Cl,Antibody-drug conjugates linkers,McValCitPABCl,ADC Linkers,inhibit,Inhibitor
- N-[(S)-1-[[(S)-1-[[4-(Chloromethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanamide
- N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(chloromethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
- N-((S)-1-(((S)-1-((4-(Chloromethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
- CAS:
- 1639351-92-0
- MF:
- C28H39ClN6O6
- MW:
- 591.1
- Mol File:
- 1639351-92-0.mol
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Mc-Val-Cit-PAB-Cl Chemical Properties
- Boiling point:
- 915.4±65.0 °C(Predicted)
- Density
- 1.278±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, stored under nitrogen
- form
- Solid
- pka
- 13.30±0.70(Predicted)
- color
- White to off-white
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Mc-Val-Cit-PAB-Cl Usage And Synthesis
Uses
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041. DOI:10.1021/acsmedchemlett.7b00243
Mc-Val-Cit-PAB-ClSupplier
ShangHai ChuanQian Chemcial Technique Centre Gold
- Tel
- 15869524721
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Bide Pharmatech Ltd.
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- 400-400-164-7117 18317119277
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696,15000506266 15000506266
Shanghai Send Pharmaceutical Technology Co., Ltd.
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- 50266790 18317173152
- Hailey@shsendpharm.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com