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Mc-Val-Cit-PAB-Cl

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Mc-Val-Cit-PAB-Cl Basic information

Product Name:
Mc-Val-Cit-PAB-Cl
Synonyms:
  • Mc-Val-Cit-PAB-Cl
  • L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(chloromethyl)phenyl]-
  • Mc Val Cit PAB Cl,Antibody-drug conjugates linkers,McValCitPABCl,ADC Linkers,inhibit,Inhibitor
  • N-[(S)-1-[[(S)-1-[[4-(Chloromethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanamide
  • N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(chloromethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
  • N-((S)-1-(((S)-1-((4-(Chloromethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
CAS:
1639351-92-0
MF:
C28H39ClN6O6
MW:
591.1
Mol File:
1639351-92-0.mol
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Mc-Val-Cit-PAB-Cl Chemical Properties

Boiling point:
915.4±65.0 °C(Predicted)
Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
-20°C, stored under nitrogen
form 
Solid
pka
13.30±0.70(Predicted)
color 
White to off-white
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Mc-Val-Cit-PAB-Cl Usage And Synthesis

Uses

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041. DOI:10.1021/acsmedchemlett.7b00243

Mc-Val-Cit-PAB-ClSupplier

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