Calcipotriol Monohydrate Chemical Properties

storage temp. 

4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.

solubility 

Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.

form 

Powder

color 

White to off-white

Stability:

Hygroscopic, Light sensitive

InChIKey

XBKHACNRWFKJNC-IZXATKCONA-N

SMILES

C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|

Calcipotriol Monohydrate Usage And Synthesis

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D₃). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Vitamin D analogue.

Definition

ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.

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