Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Pharmaceutical Impurity Reference Standards >  CALCIPOTRIOL MONOHYDRATE

CALCIPOTRIOL MONOHYDRATE

Basic information Safety Supplier Related

CALCIPOTRIOL MONOHYDRATE Basic information

Product Name:
CALCIPOTRIOL MONOHYDRATE
Synonyms:
  • CALCIPOTRIOL MONOHYDRATE
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate
  • (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate
  • 1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)-
  • Calcipotriol (Calcipotriene) Monohydrate
  • Calcipotriol monohydrate CRS
  • (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate
CAS:
147657-22-5
MF:
C27H42O4
MW:
430.63
EINECS:
689-035-6
Product Categories:
  • API
  • API intermediates
Mol File:
147657-22-5.mol
More
Less

CALCIPOTRIOL MONOHYDRATE Chemical Properties

storage temp. 
4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility 
Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form 
Powder
Stability:
Hygroscopic, Light sensitive
InChIKey
XBKHACNRWFKJNC-IZXATKCONA-N
SMILES
C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|
More
Less

CALCIPOTRIOL MONOHYDRATE Usage And Synthesis

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Vitamin D analogue.

Definition

ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.

CALCIPOTRIOL MONOHYDRATESupplier

Jiangxi ravel Biotechnology Co.,Ltd Gold
Tel
400-880-2824 15608648206
Email
1987516016@qq.com
Zhengzhou Kangshan Biological Co., Ltd. Gold
Tel
+86-0371-55023472 +86-13663848272
Email
2584787837@qq.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
Wuhan Sunrise Technology Development Co., Ltd.
Tel
027-027-83314682 13554138826
Email
whsrtech@vip.163.com
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Email
buy@fortunachem.com