FLURBIPROFEN-D3 Chemical Properties

Melting point:

108-110°C

storage temp. 

-20°C Freezer

solubility 

DMF: 25 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.9 mg/ml

form 

A solid

color 

White to off-white

FLURBIPROFEN-D3 Usage And Synthesis

Description

Flurbiprofen-d₃ is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC₅₀s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively). In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats. Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg. Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.

Chemical Properties

White Solid

Uses

An Isotopically labeled analog of Flurbiprofe

Uses

An isotopically labelled analog of Flurbiprofen (F598700).

FLURBIPROFEN-D3(1185133-81-6)Related Product Information

• Flurbiprofen