6-Methyl-2-(methylthio)pyrimidin-4-ol Chemical Properties

Melting point:

224-226°C

Boiling point:

259.2±23.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

pka

8.24±0.50(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39-24/25

WGK Germany 

3

HS Code 

29335990

6-Methyl-2-(methylthio)pyrimidin-4-ol Usage And Synthesis

Chemical Properties

White solid

Synthesis

Sodium hydroxide (97%, 15.7 g, 381 mmol) was added to 500 mL of water and the suspension was stirred for 10 min at room temperature. 6-Methyl-2-thioxasulfinyl-1,2,3,4-tetrahydropyrimidin-4-one (98%, 53.5 g, 369 mmol) was added and the mixture was stirred until completely dissolved for 10 minutes. Iodomethane (28.99 mL, 461 mmol) was slowly added dropwise and the reaction mixture continued to be stirred for 4 hours at room temperature. After completion of the reaction, a colorless solid was obtained by filtration, washed with ice-cold water (2 x 100 mL) and dried under vacuum at 60 °C to give 6-methyl-4-hydroxy-2-methylthiopyrimidine (57 g, 98% yield) as a colorless solid. The product was analyzed by LC-MS: m/z = 156.9 [M + H]+; retention time (RT) = 0.61 min.

References

[1] Patent: WO2017/59191, 2017, A1. Location in patent: Paragraph 00126-00129
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 18, p. 3025 - 3030
[3] Archiv der Pharmazie, 1984, vol. 317, # 5, p. 425 - 430

6-Methyl-2-(methylthio)pyrimidin-4-ol(6328-58-1)Related Product Information

• Bensulfuron methyl
• Methyl acrylate
• Sulfamerazine
• 2-Methylpyrimidine
• METHYL THIOPHENE-2-CARBOXYLATE
• Pirimiphos-methyl
• ISOMETHIOZIN
• Dimethyl sulfide
• Methylparaben
• Kresoxim-methyl
• Thiophanate-methyl
• Methyl
• Methyl bromide
• Parathion-methyl
• 6-Hydroxy-2-(methylsulfanyl)-4-pyrimidinecarboxylic acid
• 4-HYDROXY-6-METHOXYMETHYL-2-(METHYLTHIO)PYRIMIDINE
• 6-Methyl-2-(methylthio)pyrimidin-4-ol
• BUTTPARK 9\02-47