ALEXIDINE DIHYDROCHLORIDE Chemical Properties

Melting point:

220-224

Boiling point:

574.5±60.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Methanol (Slightly)

form 

Solid

pka

12.34±0.10(Predicted)

color 

White to Off-White

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

Hazard Note 

Irritant

HS Code 

29224995

ALEXIDINE DIHYDROCHLORIDE Usage And Synthesis

Chemical Properties

White Powder with Light Yellow Cast

Originator

Alexidine ,Science Lab.

Uses

Alexidine Dihydrochloride has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.

Definition

ChEBI: An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.

Manufacturing Process

A mixture of 16 g (0.09 mole) 1,1'-hexamethylene-bis(3-cyanoguanidine) and 20 d (0.12 mole) 2-ethylhexylamine hydrochloride is heated at 150-155°C for 3 hours. The mixture is cooled and the product is dissolved in 75 ml of hot water. The solution is treated with activated charcoal. 1,1'-Hexamethylene-bis- (5-(ethylhexyl)biguanide) is recrystalluized from methanol-ether, melting point 220.6-223.4°C.

Therapeutic Function

Antiseptic

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