H-L-CYS(TRT)-NH2 HCL Chemical Properties

Boiling point:

543.2±50.0 °C(Predicted)

Density 

1.203±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka

15.83±0.50(Predicted)

form 

Powder

color 

Off-white

H-L-CYS(TRT)-NH2 HCL Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

(2R)-2-Amino-3-[(triphenylmethyl)thio]propanamide is a useful building block for organic synthesis.

Synthesis

General procedure for the synthesis of S-trityl-L-cysteamine from (9H-fluoren-9-yl)methyl (R)-(1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate: (R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate (4 g. 6.84 mmol) was dissolved in N,N-dimethylformamide (20 mL), piperidine (0.14 mL, 1.368 mmol) was added and the reaction was carried out for 4 h at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was washed with saturated aqueous sodium chloride solution and subsequently extracted with dichloromethane. The organic phase was dried with anhydrous sodium sulfate, concentrated and purified by column chromatography (eluent: methanol/dichloromethane, 1%-5% gradient) to afford the title product S-trityl-L-cysteamine as a yellow oil (2.3 g, yield: 92%).

References

[1] Patent: CN106432014, 2017, A. Location in patent: Paragraph 0079; 0083; 0084; 0085; 0119; 0123; 0124; 0125
[2] Patent: WO2008/116302, 2008, A1. Location in patent: Page/Page column 43-44

H-L-CYS(TRT)-NH2 HCL(166737-85-5)Related Product Information

• L-Glutamine
• N-[S-Trityl-L-cysteinyl]glycine
• H-L-Cys(Trt)-OtBu*HCl
• S-Trityl-L-cysteine
• H-L-CYS(TRT)-NH2 HCL