NOURSEOTHRICIN SULFATE Chemical Properties

storage temp. 

2-8°C

solubility 

H2O: soluble200mg/mL

form 

solid

color 

white to light brown

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

RD4240000

F 

10

HS Code 

2941900000

MSDS

• Language:English Provider:SigmaAldrich

NOURSEOTHRICIN SULFATE Usage And Synthesis

Uses

Streptothricin sulfate is a broad spectrum antibacterial compound with antiviral activity.

Biological Activity

nourseothricin is a broad-spectrum antibiotic.nourseothricin is a broad-spectrum antibiotic derived from streptomyces noursei.

in vitro

nourseothricin, represents a mixture of streptothricins, mainly d and f. although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. it has been also shown that nourseothricin was able to generate some channels into the outer membrane. moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. in addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1].

in vivo

animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. there was a high degree of accumulation of nourseothricin in renal cortical slices. in contrast to pah accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. age dependent differences in nourseothricin accumulation did not exist [2].

References

[1] seltmann g. resistance of escherichia coli to nourseothricin (streptothricin): sensitization of resistant strains by abolition of its outer membrane resistance. zentralbl bakteriol. 1992 jan;276(2):143-51.
[2] brunlich h, hoffmann h, bocker h. renal handling of nourseothricin. pharmazie. 1988 mar;43(3):200-2.

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