CGP 52432 Chemical Properties

Boiling point:

544.4±50.0 °C(Predicted)

Density 

1.258±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: soluble1mg/mL, clear (warmed)

form 

powder

pka

2.26±0.50(Predicted)

color 

white to beige

Water Solubility 

Soluble in water (10mM, gentle warming)

Safety Information

WGK Germany 

3

CGP 52432 Usage And Synthesis

Uses

CGP52432 has been used as a γ-aminobutyric acid B (GABA_B) antagonist:

• to study its effects on the simulation of the onset of status epilepticus (SE) in mice
• for voltage-clamp recording in mice neurons
• to study its effects on the GABA_B receptor-mediated neurotransmission in guinea pig hippocampus

Definition

ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.

Biological Activity

Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).

Biochem/physiol Actions

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.

storage

+4°C (desiccate)

CGP 52432(139667-74-6)Related Product Information

• BENZYL ISOTHIOCYANATE
• Methylene dithiocyanate
• TRIMETHYLSILYL ISOTHIOCYANATE
• Hypophosphorous acid
• CGP 35348
• CGP 52432
• 3-AMINOPROPYL(METHYL)PHOSPHINIC ACID HCL