Climbazole Chemical Properties

Melting point:

96-100°C

Boiling point:

447.5±40.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

vapor pressure 

0.001Pa at 25℃

refractive index 

1.54

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Insoluble in water

pka

5.66±0.22(Predicted)

color 

White to Almost white

Water Solubility 

58mg/L at 25℃

BRN 

618020

InChIKey

OWEGWHBOCFMBLP-UHFFFAOYSA-N

LogP

3.83 at 25℃

CAS DataBase Reference

38083-17-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50/53

Safety Statements 

60-61

RIDADR 

UN 3077

WGK Germany 

3

RTECS 

EL7085000

HS Code 

29332900

Climbazole Usage And Synthesis

Risks to the environment

Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.

Description

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

Chemical Properties

White Solid

Uses

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

Definition

ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.

Hazard

Moderately toxic by ingestion. Low toxicity by skin contact.

Flammability and Explosibility

Non flammable

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.

Climbazole(38083-17-9)Related Product Information

• Imidazole
• Dimethyl sulfide
• N,N-Dimethylformamide
• Dimethyl sulfoxide
• 1-Vinylimidazole
• Dimethyl phthalate
• Dimethyl fumarate
• Dimethyl ether
• 4-Methyl-2-pentanone
• 2-Butanone oxime
• ETHANE
• Tetra-(methylethylketoxime)silane
• Dimethyldimethoxysilane
• 1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE
• 1-AMINO-3,3-DIMETHYL-BUTAN-2-ONE HYDROCHLORIDE
• PHENOXYACETONE
• 1-(4-CHLOROPHENOXY)-2-PROPANONE
• 2-Propanone, 1-(1H-imidazol-1-yl)- (9CI)