N-Formylmorpholine Chemical Properties

Melting point:

20-23 °C (lit.)

Boiling point:

236-237 °C (lit.)

Density 

1.145 g/mL at 25 °C (lit.)

vapor pressure 

0.03 hPa (20 °C)

refractive index 

n20/D 1.485(lit.)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

SOLUBLE

pka

-0.75±0.20(Predicted)

form 

Liquid

color 

Clear yellow

PH

10 (250g/l, H2O, 20℃)

explosive limit

1.2-8.2%(V)

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

BRN 

110293

LogP

-1.2 at 23℃

CAS DataBase Reference

4394-85-8(CAS DataBase Reference)

NIST Chemistry Reference

N-Formylmorpholine(4394-85-8)

EPA Substance Registry System

4-Morpholinecarboxaldehyde (4394-85-8)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

23-24/25

WGK Germany 

3

RTECS 

QD9694000

Autoignition Temperature

345 °C DIN 51794

TSCA 

Yes

HS Code 

29349990

Toxicity

LD50 orally in Rabbit: > 7360 mg/kg LD50 dermal Rabbit > 18400 mg/kg

MSDS

• Language:English Provider:4-Morpholinecarboxaldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Formylmorpholine Usage And Synthesis

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-Formylmorpholine is widely used as a solvent and extracting agent for aromatics. It is used as a scrubbing agent for acidic gases. It is employed in the preparation of adenine hydrochloride labeled with 14C, 4-(trifluoromethyl)morpholine, 3-alkyl-2-chloro-5,6-dihydrobenzaldehyde and terphenyl dialdehyde. It plays an important role in the desulfurization of natural gas, synthetic gas, flue gas and gasoline.

Uses

4-Formylmorpholine has been used in the preparation of:

• adenine hydrochloride labelled with ¹⁴C
• terphenyl dialdehyde

Synthesis Reference(s)

The Journal of Organic Chemistry, 25, p. 199, 1960 DOI: 10.1021/jo01072a012

General Description

Treatment of 4-formylmorpholine with sulphur tetrafluoride in the presence of potassium fluoride gives 4-(trifluoromethyl)morpholine in excellent yields. 4-Formylmorpholine reacts with series of 2-alkyl-2-cyclohexen-1-ones in the presence of POCl₃ to give the corresponding 3-alkyl-2-chloro-5,6-dihydrobenzaldehydes and allylic alcohols (by-product).

Flammability and Explosibility

Non flammable

N-Formylmorpholine(4394-85-8)Related Product Information

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• Tridemorph
• Moroxydine
• Formaldehyde
• Dimethomorph
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• 4-Morpholinecarbonyl chloride
• N-DECANOYLMORPHOLINE
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• N-NONANOYLMORPHOLINE