ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Aromatics > 4-CYANO-2-METHOXYBENZALDEHYDE
4-CYANO-2-METHOXYBENZALDEHYDE
4-CYANO-2-METHOXYBENZALDEHYDE Basic information
- Product Name:
- 4-CYANO-2-METHOXYBENZALDEHYDE
- Synonyms:
-
- 4-CYANO-2-METHOXYBENZALDEHYDE
- 4-Cyaon-2-methoxybenzaldehyde
- 2-Methoxy-4-cyanobenzaldehyde
- 4-forMyl-3-Methoxybenzonitrile
- 4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde)
- Benzonitrile, 4-formyl-3-methoxy-
- 4-Formyl-3-methoxybenzonitrile (or) 4-Cyano-2-Methoxy Benzaldehyde
- 4-Cyano-2-neneneba methoxy Benzaldehyde
- CAS:
- 21962-45-8
- MF:
- C9H7NO2
- MW:
- 161.16
- EINECS:
- 804-777-4
- Product Categories:
-
- Intermediate
- 21962-45-8
- Mol File:
- 21962-45-8.mol
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4-CYANO-2-METHOXYBENZALDEHYDE Chemical Properties
- Melting point:
- 109-111℃
- Boiling point:
- 318℃
- Density
- 1.18
- vapor pressure
- 0.003-2.3Pa at 20-80℃
- Flash point:
- 138℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- InChI
- InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
- InChIKey
- ZXENVSJZOHXCKL-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(C=O)C(OC)=C1
- LogP
- 1.42 at 20℃ and pH7
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4-CYANO-2-METHOXYBENZALDEHYDE Usage And Synthesis
Synthesis
79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde is obtained as a white solid.
4-CYANO-2-METHOXYBENZALDEHYDESupplier
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