2,3-Difluorobenzaldehyde Chemical Properties

Melting point:

64-65 °C

Boiling point:

64-65 °C/17 mmHg (lit.)

Density 

1.301 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.499(lit.)

Flash point:

137 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

Specific Gravity

1.301

color 

Clear pale yellow

Sensitive 

Air Sensitive

BRN 

2961554

InChI

InChI=1S/C7H4F2O/c8-6-3-1-2-5(4-10)7(6)9/h1-4H

InChIKey

WDBAXYQUOZDFOJ-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=CC(F)=C1F

CAS DataBase Reference

2646-91-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36/37

RIDADR 

UN 1989 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29130000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,3-Difluorobenzaldehyde Usage And Synthesis

Chemical Properties

clear pale yellow liquid

Uses

2,3-Difluorobenzaldehyde was used in the synthesis of aminophosphine.

General Description

The emission and absorption spectra of 2,3-difluorobenzaldehyde were studied.

Synthesis

The general steps for the synthesis of 2,3-difluorobenzaldehyde from 2,3-difluorotoluene are as follows: (1) Preparation of the device: connect the tubular reactor as shown in Fig. 2, and choose a combination of pipes with (3a + 3c) DC channels and inclined square pancake-type variable diameter flat pipes. Determine the pipe diameter and volume according to the experimental needs. (2) Solution preparation: 6.06 g of cobalt acetate and 6.06 g of sodium molybdate were dissolved in 200 mL of acetic acid containing 200 mg of 2,3-difluorotoluene to form a mixed solution, ensuring that n (cobalt acetate): n (2,3-difluorotoluene) = 0.015:1. Meanwhile, 6.06 g of sodium bromide was dissolved in 35% H2O2 to prepare a H2O2-acetic acid solution, adjusting n (sodium bromide): n(2,3-difluorotoluene) = 0.015: 1. (3) Reaction process: 2,3-difluorotoluene-acetic acid solution and H2O2-acetic acid solution were injected into a continuous heat exchanger tubular reactor through a constant-flow pump at a flow rate of 5.56 ml/min and 11.11 ml/min, respectively, to ensure that n(H2O2): n(2,3-difluorotoluene) = 2:1. The reaction was carried out in a microchannel reactor with a set reaction temperature of 120 °C and a residence time of 1500 s. (4) Post-treatment: after completion of the reaction, the outlet material was cooled and the reaction was quenched with dichloromethane. The conversion of 2,3-difluorotoluene was determined to be 65.1% and the yield of 2,3-difluorobenzaldehyde was 48.2% by GC analysis.

References

[1] Patent: CN106748682, 2017, A. Location in patent: Paragraph 0052-0054
[2] Kogyo Kagaku Zasshi, 1956, vol. 59, p. 1160
[3] Chem.Abstr., 1958, p. 13265

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