PYR-GLU-PRO-NH2
PYR-GLU-PRO-NH2 Basic information
- Product Name:
- PYR-GLU-PRO-NH2
- Synonyms:
-
- pyroglutamyl-glutamyl-prolineamide
- fertilization promoting peptide
- GLP-GLU-PRO-NH2: GLP-EP-NH2
- pGlu-Glu-Pro-NH2
- PYR-GLU-PRO-NH2
- PYROGLU-GLU-PRO AMIDE
- PGLU-GLU-PRO AMIDE
- PE-E-P-NH2
- CAS:
- 85541-78-2
- MF:
- C15H22N4O6
- MW:
- 354.36
- Mol File:
- 85541-78-2.mol
PYR-GLU-PRO-NH2 Chemical Properties
- Boiling point:
- 899.9±65.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Solid
- pka
- 4.47±0.10(Predicted)
- color
- White to off-white
MSDS
- Language:English Provider:SigmaAldrich
PYR-GLU-PRO-NH2 Usage And Synthesis
Uses
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].
Definition
ChEBI: Pglu-glu-pro-amide is an oligopeptide.
in vivo
(Glu2)-TRH (1-100 μmol/kg; IV) dose-dependently attenuated TRH-induced analeptic action[1].
(Glu2)-TRH (10 μmol/kg; IV) 10 min before Pentobarbital (60 mg/kg; i.p.) decreases the sleeping time by approximately 20% compared to the vehicle treated group[1].
| Animal Model: | Male Swiss-Webster mice (30 g)[1] |
| Dosage: | 1, 2, 5, 10, 15, 25, 50, 100 μmol/kg |
| Administration: | IV; 10 min before Pentobarbital (60 mg/kg, i.p.) |
| Result: | Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action. |
References
[1] Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6. DOI:10.1016/j.brainresbull.2010.02.007
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