5-Nitrobenzimidazole Chemical Properties

Melting point:

207-210 °C

Boiling point:

290.19°C (rough estimate)

Density 

1.4141 (rough estimate)

bulk density

270kg/m3

refractive index 

1.5500 (estimate)

storage temp. 

Store below +30°C.

solubility 

0.5g/l

pka

10.95±0.10(Predicted)

form 

Solid

color 

Light Beige

PH

6 (10g/l, H2O, 20℃)(slurry)

Water Solubility 

<0.01 g/100 mL at 16.5 ºC

BRN 

7926

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.

CAS DataBase Reference

94-52-0(CAS DataBase Reference)

EPA Substance Registry System

5-Nitrobenzimidazole (94-52-0)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-40-22

Safety Statements 

26-45-36/37

RIDADR 

2811

WGK Germany 

3

RTECS 

DD9800000

TSCA 

Yes

HS Code 

29339990

Hazardous Substances Data

94-52-0(Hazardous Substances Data)

MSDS

• Language:English Provider:5-Nitrobenzimidazole
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-Nitrobenzimidazole Usage And Synthesis

Chemical Properties

white or pale yellow powder

Uses

Antifogging agent in photographic developers.

Uses

5-Nitrobenzimidazole acts as a reagent in the synthesis of benzimidazoles derivatives with antibacterial and antifungal activities. It also functions as a reagent in the synthesis of xanthine oxidase, a key enzyme that catalyze xanthine to uric acid causing hyperuricemia in humans.

General Description

Off-white to pale yellow fluffy powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

5-Nitrobenzimidazole is incompatible with strong oxidizing agents and strong bases.

Fire Hazard

Flash point data for 5-Nitrobenzimidazole are not available but 5-Nitrobenzimidazole is probably combustible.

Synthesis

First, 4-nitrophthalimide (1 g) was mixed with formic acid (0.74 mL) in 5N hydrochloric acid (70 mL), stirred and heated to reflux for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, neutralized with 10% sodium hydroxide solution and the precipitate was isolated. Subsequently, the precipitate was recrystallized with water and dried to give 5-nitrobenzimidazole (0.69 g) [37].

References

[1] Molecules, 2015, vol. 20, # 8, p. 15206 - 15223
[2] Journal of the Korean Chemical Society, 2010, vol. 54, # 5, p. 589 - 593
[3] Journal of the Chilean Chemical Society, 2012, vol. 57, # 2, p. 1122 - 1125,4
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9591 - 9600
[5] Journal of the Chemical Society of Pakistan, 2018, vol. 40, # 2, p. 366 - 374

5-Nitrobenzimidazole(94-52-0)Related Product Information

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