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3-Nitro-L-tyrosine

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3-Nitro-L-tyrosine Basic information

Product Name:
3-Nitro-L-tyrosine
Synonyms:
  • (2R)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid
  • L-Tyrosine, 3-nitro-
  • 3-Nitro-L-tyrosine,99%
  • (S)-2-aMino-3-(4-hydroxy-3-nitrophenyl)propanoic acid
  • Z-D-Dap(Boc)
  • 3-NITRO-L-TYROSINE (RING-13C6)
  • (S)-3-(3-Nitro-4-hydroxyphenyl)alanine
  • 3-Nitro-L-tyrosine≥ 98% (Assay)
CAS:
621-44-3
MF:
C9H10N2O5
MW:
226.19
EINECS:
210-688-6
Product Categories:
  • Pharmaceutical Raw Materials
  • Amino Acids
  • Tyrosine [Tyr, Y]
  • Unusual Amino Acids
  • Oxidative Stress Proteins and ReagentsPeptide Synthesis
  • Cell Stress
  • Peptide Synthesis
  • Tyrosine Derivatives
  • Unnatural Amino Acid Derivatives
  • Nitric Oxide and Cell Stress
  • Amino Acids & Derivatives
  • Aromatics
Mol File:
621-44-3.mol
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3-Nitro-L-tyrosine Chemical Properties

Melting point:
233-235 °C (dec.) (lit.)
alpha 
4 º (c=1, 1N HCl)
Boiling point:
367.79°C (rough estimate)
Density 
1.4160 (rough estimate)
refractive index 
1.5373 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Aqueous Acid (Slightly), Water
pka
2.17±0.20(Predicted)
form 
crystalline
color 
yellow to green
Water Solubility 
insoluble
BRN 
2813157
CAS DataBase Reference
621-44-3(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-37/39-26-36
WGK Germany 
3
HS Code 
29225090

MSDS

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3-Nitro-L-tyrosine Usage And Synthesis

Description

Nitrotyrosine is formed by peroxynitrite-mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation in vivo. Both free and protein-bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions. The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.

Chemical Properties

ochre-yellow to yellow-green powder

Uses

A marker for peroxynitrite. Oxidant and cytotoxic agent.

Uses

3-Nitro-L-tyrosine is used as an indicator of the formation of peroxynitrite by NO-dependent oxidative damage.

Definition

ChEBI: 3-nitro-L-tyrosine is a 3-nitrotyrosine comprising L-tyrosine having a nitro group at the 3-position on the phenyl ring. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and a 3-nitrotyrosine. It is an enantiomer of a 3-nitro-D-tyrosine.

Biochem/physiol Actions

Oxidant and cytotoxic agent.

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