Basic information Safety Supplier Related

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Basic information Safety Supplier Related

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Basic information

Product Name:
N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
Synonyms:
  • MGBPJXVWDGGLKI-GBIKJYCISA-M
  • dibutyryl cyclic 3',5'-guanosine monophosphate, sodium
  • N2,2μ-O-Dibutyrylguanosine 3μ,5μ-cyclic monophosphate hydrate sodium salt
  • Guanosine 3,5-cyclic Monophosphate, N2,2-O-Dibutyryl-, Sodium Salt - CAS 51116-00-8 - Calbiochem
  • N2,2μ-O-Dibutyrylguanosine 3μ,5μ-cyclic monophosphate dihydrate sodium salt
  • N,2'-O-Dibutyrylguanosine 3',5'-phosphoric acid
  • N2,2'-O-Dibutyryl cGMP
  • Dibutyryl-Cyclic GMP (sodium salt)
CAS:
51116-00-8
MF:
C18H23N5NaO9P
MW:
507.37
EINECS:
2569922
Product Categories:
  • Biochemicals and Reagents
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleotide Analogs
  • Cyclic Nucleotide Metabolism
  • Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology
  • G Proteins and Cyclic Nucleotides
  • Protein Kinase G (PKG)
  • Serine/Threonine Kinase Activators
Mol File:
51116-00-8.mol
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N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Chemical Properties

storage temp. 
−20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
off-white
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Safety Information

WGK Germany 
3
F 
10-21

MSDS

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N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Usage And Synthesis

Description

Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase. It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.

Uses

Dibutyryl-cGMP is a membrane permeable cGMP analog.

in vivo

Dibutyryl-cGMP (50-200?μg/paw; subcutaneous injection; male Wistar rats) treatment antagonizes the hyperalgesic effect of PGE2 in a dose-dependent manner. Maximal antinociceptive effect of DbcGMP is at 1?h after administration and last for plus 2?h[3].

Animal Model:Male Wistar rats (180-?250?g) injection with Prostaglandin E2 (PGE2)[3]
Dosage:50 μg/paw, 75 μg/paw, 100 μg/paw and 200?μg/paw
Administration:Subcutaneous injection
Result:Antagonized the hyperalgesic effect of PGE2 (2?μg/paw), in a dose-dependent manner.

References

[1] M. CATALDI . Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells[J]. Biochimica et biophysica acta. Molecular cell research, 1999, 1449 2: Pages 186-193. DOI: 10.1016/s0167-4889(99)00013-0
[2] NICHOLAS J. WILLMOTT  Antony G  Judith Asselin. Calcium store depletion potentiates a phosphodiesterase inhibitor- and dibutyryl cGMP-evoked calcium influx in rat pituitary GH3 cells[J]. FEBS Letters, 1996, 386 1: 39-42. DOI: 10.1016/0014-5793(96)00413-9
[3] S S KAPLAN. Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP.[J]. Blood, 1989, 74 6: 1885-1887.
[4] C. CHIK. cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes[J]. Journal of Neuroscience, 1995, 2 1: 3104-3109. DOI: 10.1523/jneurosci.15-04-03104.1995
[5] T A ROONEY. Cyclic GMP induces oscillatory calcium signals in rat hepatocytes.[J]. The Journal of Biological Chemistry, 1996, 271 33: 19817-19825. DOI: 10.1074/jbc.271.33.19817

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALTSupplier

Shanghai Aladdin Bio-Chem Technology Co.,LTD
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT(51116-00-8)Related Product Information