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Loxapine succinate salt

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Loxapine succinate salt Basic information

Product Name:
Loxapine succinate salt
Synonyms:
  • cl71563
  • daxoline
  • lederle
  • loxapac
  • loxitane
  • oxazepine(1:1)
  • succinicacid,compd.with2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)
  • succinicacid,compd.with2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine(1:1)
CAS:
27833-64-3
MF:
C22H24ClN3O5
MW:
445.9
EINECS:
248-682-0
Product Categories:
  • API
  • DILABIL
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Antagonists
  • neurochemistry
  • Dopaminergics
  • Neurotransmitters
Mol File:
27833-64-3.mol
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Loxapine succinate salt Chemical Properties

Melting point:
150-152°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
form 
solid
color 
white
CAS DataBase Reference
27833-64-3(CAS DataBase Reference)
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Safety Information

RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
WM5750000
HS Code 
29329990

MSDS

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Loxapine succinate salt Usage And Synthesis

Description

Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.

Description

Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.

Chemical Properties

White to Of-White Solid

Uses

A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent

Uses

choleretic

Uses

Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.

brand name

Loxapine (Mylan); Loxitane (Watson).

Toxicity evaluation

Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.

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