2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE Chemical Properties

Melting point:

115-116.5℃

Boiling point:

281.6±35.0 °C(Predicted)

Density 

1.504±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-0.83±0.39(Predicted)

Appearance

Light brown to brown Solid

InChI

InChI=1S/C5H5Cl2N3/c1-2-3(8)4(6)10-5(7)9-2/h8H2,1H3

InChIKey

FDMMHWIFYCXEOF-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(C)=C(N)C(Cl)=N1

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-41

Safety Statements 

26-39

HS Code 

2933599590

2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE Usage And Synthesis

Uses

2,4-dichloro-6-methylpyrimidin-5-amine is an amine compound that can be used as a pharmaceutical intermediate or raw material for organic synthesis.

Synthesis

2,4-Dichloro-5-nitro-6-methylpyrimidine (860 mg) was used as a feedstock and co-dissolved with Pd/C (180 mg) in ethyl acetate (30 mL). Hydrogen was passed three times at room temperature to displace the air in the reaction system, followed by the reaction at 40 psi hydrogen pressure. Upon completion of the reaction, the Pd/C catalyst was removed by filtration to afford the yellow solid product 2,4-dichloro-5-amino-6-methylpyrimidine (500 mg) in 65.1% yield.

References

[1] Heterocyclic Communications, 2014, vol. 20, # 5, p. 275 - 279
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0032
[3] Journal of Heterocyclic Chemistry, 2016, vol. 53, # 3, p. 832 - 839
[4] Journal of the American Chemical Society, 1954, vol. 76, p. 1953
[5] Yakugaku Zasshi, 1942, vol. 62, p. 315,333; dtsch. Ref. S. 95, 106

2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE(13162-27-1)Related Product Information

• 2,4-DICHLORO-5-NITRO-6-PHENYLPYRIMIDINE
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• 2,4-dichloro-6-cyclopropyl-5-nitropyrimidine
• ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE
• 2,4-Dichloro-6-methyl-5-nitropyrimidine
• 2,4-DICHLORO-6-(TRIFLUOROMETHYL)PYRIMIDIN-5-AMINE
• 2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE