ISOPILOCARPINE Chemical Properties

Boiling point:

261 °C/IO mm

pka

pKa 7.18(H2O,t =15) (Uncertain)

ISOPILOCARPINE Usage And Synthesis

Description

The leaves of Pilocarpus pennatifolius Lem. and P. jaborandi Holmes contain this alkaloid which is a colourless oily liquid. A number of salts and derivatives have been prepared, e.g. the hydrochloride hemihydrate, m.p. 127°C or 159°C (dry); hydrobromide, m.p. 147°C; nitrate, m.p. 159°C; aurichloride, m.p. 158-9°C; platinichloride, m.p. 226-7°C; picrate, m.p. 161°C and the methiodide, m.p. 114°C.

References

Jowett.,J. Chern. Soc., 77, 483 (1900) Jowett., ibid, 87, 794 (1905) Burtles, Pyman, Roylance., ibid, 581 (1925) Preobrashenski, Wompe, Preobrashenski., Ber., 66, 1187 (1933) Poljakova et al., ibid, 69, 1314 (1936) DeY.,J. Chern. Soc., 1057 (1937) Preobrashenski., Chern. Abstr., 47,4345 (1953)