Clobetasol Chemical Properties

Melting point:

220-222°C

Boiling point:

555.1±50.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

12.03±0.70(Predicted)

color 

White to Light Brown

Safety Information

Hazard Codes 

T

Risk Statements 

61-48/20/21-53-62

Safety Statements 

53-36/37-45

Hazardous Substances Data

25122-41-2(Hazardous Substances Data)

Clobetasol Usage And Synthesis

Chemical Properties

White to Off-White Solid

Originator

Dermovate,Glaxo,UK,1973

Uses

Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.

Uses

Atorvastatin Intermediate

Definition

ChEBI: A 3-oxo-Delta1,Delta4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha posit ons, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis.

Manufacturing Process

A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.

brand name

Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).

Therapeutic Function

Corticosteroid, Antiinflammatory

Clobetasol(25122-41-2)Related Product Information

• Betamethasone-17-ketone
• Betamethasone EP Impurity D
• Betamethasone Impurity 35
• 11-Oxo-betaMethasone Dipropionate
• Mometasone furoate
• Trimethyl borate
• Dexamethasone
• 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
• 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione
• Ethanone, 2-chloro-1-cyclopentyl- (9CI)
• CLOBETASOL PROPIONATE RELATED COMPOUND A (50 MG) (9-ALPHA-FLUORO-11-BETA-HYDROXY-16-BETA-METHYL-3-OXO-ANDROSTA-1,4-DIENE-17(R)-SPIRO-2'-[4'-CHLORO-5'-ETHYLFURAN-3'(2'H)-ONE])
• Halobetasol propionate
• Clobetasol propionate
• CLOBETASOL FOR PEAK IDENTIFICATION,CLOBETASOL FOR PEAK IDENTIFICATION
• CLOBETASOL IMPURITY J,CLOBETASOL IMPURITY J
• HALOBETASOL
• Clobetasol
• fluoro jade